FWIW, we removed the OEM mattress and base (its too short) and replaced it with a sleep number bed. I actually added 3/4" plywood as a stronger base under the bed and mounted the air compressor under it out of harms way. Love the sleep number.
Just be sure to deflate it before changing altitudes...
2014 Redwood 38BR, Fulltiming
2013 Ford F-350 CCSB 6.7L 4x4 SRW, B&W Companion Hitch, Air Bags